Molecular docking, Synthesis and Characterization of New Indomethacin and Mefenamic Acid Analogues as Potential Anti-inflammatory Agents

In this work the pharmacological study and synthesis of new thiadiazine bearing on triazole which obtained from hippuric acid , indomethacin mefenamic that have carboxylic moiety, Drugs with groups thiocarbohydrazide interacted to produce 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol (1a-c).
 starting products 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol) were treated chloroacetyl chloride final (2a-c). To confirm structure generated compounds, FT-IR, 1H-NMR, mass spectroscopy used characterize all derivatives (intermediate products). The in vivo anti-inflammatory efficacy some thier toxicity animals (in vivo) evaluated. And then subjected molecular docking create safe efficient molecules. test each derivative's ability bind enzyme's active site, it was docked into sites. determine synthetic compound's topological polar surface area, bioavailability, drug-likeness, An investigation absorption, distribution, metabolism elimination performed. According findings, tested adhered Lipinski rule ingested